The 3rd Global Conference on Agricultural Research for Development (GCARD3) formally opened on Tuesday evening, 5 April 2016, at the Birchwood Hotel and O.R. Tambo Conference Centre in Boksburg, South Africa. Addressing the overall theme of ‘No One Left Behind; Agri–food Innovation and Research for a Sustainable World,’ the Conference is part of a two-year consultative process to build collective actions to transform and strengthen agricultural research and innovation systems in line with the vision developed through GCARD1 and expressed as joint initiatives among GCARD2 stakeholders.